How Long After Amoxicillin Can I Take Tylenol And Why?

logo by Editorial Staff | Updated on August 3rd, 2022

Exact answer: There were no interactions discovered between amoxicillin and Tylenol. This does not imply that no interactions exist. Always seek the advice of your healthcare practitioner.

It’s fairly unusual for someone suffering from an illness to want symptom alleviation until their medication (amoxicillin in this example) takes effect.

Amoxicillin Can I Take Tylenol

The good news is that taking Tylenol (acetaminophen) with amoxicillin is safe because there is no known or documented interaction between the drugs.

Study had been done, and as many as 5×106 bacteria were put in each animal’s ear through transpolar instillation, and they were exposed to them. 

Acetaminophen was given 30 minutes before each dose of antibiotics, and it was given every time. 

They gave each 2.5 and 10 mg of Amoxicillin/clavulanic acid and erythromycin by injection at 2, 10, and 18 hours after the person was infected. Samples were taken from the middle ear on day 2 after the person was injected with the bacteria. 

Acetaminophen didn’t make any difference between animals that got it with or without antibiotics and those that didn’t.

What exactly is Amoxicillin?

Amoxicillin is well-known for its effectiveness in treating a wide range of bacterial illnesses. This medication can be used to limit bacterial growth.

Antibiotics, such as amoxicillin, are ineffective against colds, flu, and other viral illnesses. Taking medicines when not required raises your chances of developing an illness resistant to antibiotic therapy later.

Bacterial infection

Bacterial infections are caused by bacteria (germs) and are treatable with antibiotics. Bacterial infections include the following:

  • Actinomycosis
  • Anthrax Prophylaxis
  • Bacterial Endocarditis Prevention
  • Bacterial Infection
  • Bladder Infection
  • Bronchiectasis
  • Bronchitis
  • Chlamydia Infection
  • Cutaneous Bacillus anthracis
  • Dental Abscess
  • Helicobacter Pylori Infection
  • Lyme Disease, Arthritis
  • Lyme Disease, Carditis
  • Lyme Disease, Erythema Chronicum Migrans
  • Lyme Disease, Neurologic
  • Otitis Media
  • Pneumonia
  • Sinusitis
  • Skin or Soft Tissue Infection
  • Spleen Removal (off-label)
  • Tonsillitis/Pharyngitis
  • Upper Respiratory Tract Infection
  • Urinary Tract Infection

What other medications will affect amoxicillin?

Inform your doctor about all of your other medications, particularly:

Any other antibiotics; allopurinol; probenecid; or a blood thinner such as warfarin, Coumadin, or Jantoven

This is not an exhaustive list. Other pharmaceuticals may interact with amoxicillin, including prescription and over-the-counter medications, vitamins, and herbal items. This list does not include all probable medication interactions.

Side effects of amoxicillin

If you develop symptoms of an allergic response to amoxicillin (hives, difficulty breathing, swelling in your face or throat) or a severe skin reaction, get emergency medical attention (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

If you develop any of the following symptoms, contact your doctor right away:

Severe stomach ache; or watery or bloody diarrhea (even if it occurs months after your last dose).

The following are some of the most common amoxicillin adverse effects:

  • Nausea
  • Vomiting
  • Diarrhea
  • or a rash is all possible symptoms.

This is not an exhaustive list of possible adverse effects; more may arise. For medical advice on side effects, contact your doctor. You can contact the FDA at 1-800-FDA-1088 to report adverse effects.

What exactly is Tylenol?

This medication is a penicillin antibiotic. It is also used to treat stomach and intestine ulcers caused by the bacterium H.pylori. Amoxicillin cannot be used to treat viral illnesses such as the common cold or flu.

Tylenol is a medication (Acetaminophen) that is also known as paracetamol.

Tylenol is prescribed for the following conditions:

  • Fibromyalgia 
  • Muscle Pain 
  • Sciatica

There is no response seen while taking Amoxicillin and Tylenol simultaneously. There are no potential danger concerns, and it is completely safe.

What should I stay away from when taking Tylenol?

Before using any other cold, allergy, pain, or sleep drug, see your doctor or pharmacist.

Many combination medications contain acetaminophen (often abbreviated as APAP).

Taking some products together can result in an overdose of acetaminophen, which can be lethal. Check the medication’s label to discover if it includes acetaminophen or APAP.

Avoid consuming alcoholic beverages. While using Tylenol may raise your risk of liver damage.

What other medications will affect Tylenol?

Other pharmaceuticals, including prescription and over-the-counter medications, vitamins, and herbal supplements, may interact with acetaminophen. Inform all of your healthcare providers about the medications you are currently taking and any new or discontinued medications.

Stop using this medication and contact your doctor right away if you see any of the following symptoms of liver disease:

Stomach discomfort (upper right side); appetite loss; weariness, itching; dark urine, clay-colored feces; or jaundice (yellowing skin or eyes).

Less severe Tylenol side effects are more frequent, and you may have none at all.

This is not an exhaustive list of possible adverse effects; more may arise. For medical advice on side effects, contact your doctor. You can contact the FDA at 1-800-FDA-1088 to report adverse effects.

Why should I wait so long after taking amoxicillin to take Tylenol?

Amoxicillin and Tylenol are two different medications with distinct roles; one is an antibiotic, while the other is used to treat discomfort and lower fever caused by pain or inflammation.

When they are taken together, there are no adverse effects or reactions, and there is no time restriction between taking amoxicillin and Tylenol.

It’s never easy to figure out how to take amoxicillin. Because it is an antibiotic, it should be taken orally, with or without meals, according to the doctor’s instructions.

If you are taking antibiotics, you should drink lots of fluids. To get the greatest results from this antibiotic, make sure you take it at the same time every day.

Do not stop taking this medication; even if you are not experiencing any symptoms, you must continue to take the whole amount as prescribed. If you discontinue the medication before the authorized dose, you may redevelop the illness because the bacteria may continue to increase.

Tylenol should be taken as a whole or as a tablet at once; it should not be chewed or mashed while swallowing, as this may result in negative effects. Also, do not divide it unless your doctor or pharmacist has instructed you to.

Tylenol is fine for pains, fevers, or soreness, but don’t take it for more than three days without seeing any results. Consult your doctor about getting testing and determining the reason.


Before taking any drug, see your doctor see if you are allergic to it or if you have any other allergies. Because if you take such a drug without knowing, the items might include inactive chemicals that cause allergies.

It is critical to address your past health conditions with your doctor, such as if you are diabetic or pregnant, as a high dose might produce negative effects. These subjects should be discussed with your doctor.

There has been no reported interaction between Tylenol and amoxicillin up to this point, but there must be some. There may be no major negative effects from the interactions. Without the doctor’s approval, do not begin, halt, or quit any treatment.


Editorial Staff

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