How Long After Nyquil Can You Take Ibuprofen And Why?

logo by Editorial Staff | Updated on August 3rd, 2022

Exact answer: After approximately 3 hours

It is never wise or encouraged to combine drugs first consulting with your doctor. 

nyquill and tylenol

Even though NyQuil contains acetaminophen rather than ibuprofen. Many people use them for pain, heat, and even inflammation.

However, because they are different medications, mixing them could result in serious unfavorable interactions, including, but not limited to, a lethal overdose. 

Acetaminophen and Ibuprofen belong to separate groups of drugs and should never be mixed without first consulting your doctor or pharmacist. Even if others have persuaded you that it is fine since they have done it and have survived to tell you their story.

Please keep in mind that we are all unique. What worked for them can backfire on you.

Furthermore, it is impossible for anybody, including your doctor, to predict whether and how combining drugs may impact you.

What exactly is Nyquil?

Nyquil is the most commonly prescribed medicine for the treatment of discomfort, cough, and fever. There are numerous brands available, each with its own set of advantages and disadvantages.

However, all drugs are available in different countries under different brand names.

Acetaminophen is mostly used to treat pain and fever. Dextromethorphan aids in the improvement of a patient’s cough. Nyquil is primarily used to treat allergies, pain in the body, the common cold and its symptoms, and the flu.

It would not, however, be able to treat coughing produced by anything else than a regular cold. However, like any drug, this medication should only be taken as directed by a doctor. Excessive and improper use results in withdrawal symptoms and negative effects.

Nyquil interacts with MAO inhibitors such as isocarboxazid, selegiline, phenelzine, linezolid, and tranylcypromine. Persons who have taken any MAO-inhibiting drugs during the last 15 days should avoid the medication completely. 

This medication should not be taken by anyone who has asthma, stomach infections, ulcers, or kidney problems. The medicine may interact with their regular prescriptions, resulting in unfavorable outcomes.

Pregnant and nursing women should avoid these drugs. These drugs may be passed from the mother’s body to the baby, influencing the infant’s health.

These pills are antihistamines, and they even reduce the formation of milk in the newborn. Excessive use of the medicine can cause liver and renal damage, leading to death. As a result, it is frequently advised to use this drug as a doctor’s prescription.

NyQuil includes three active components (NyQuil Severe has four):

  • Acetaminophen (pain reliever/fever suppressant)
  • Doxylamine (sedating antihistamine)
  • Dextromethorphan (cough suppressant)
  • Nasal phenylephrine (NyQuil Severe)

Ingredients in Tylenol

  • 500 mg acetaminophen (in each tablet)
  • Inactive ingredients. FD&C, Pregelatinized Starch, Sodium Starch Glycolate, Magnesium Stearate, Purified Water, Powdered Cellulose Yellow no. 40 Aluminum Lake, Polyethylene Glycol, Titanium Dioxide, FD&C Red no. 40 Aluminum Lake, Polyethylene Glycol, Titanium Dioxide, FD&C Yellow no. 40 Aluminum Lake, Polyethylene Glycol,

Acetaminophen overdose

The Food and Drug Administration (FDA) warns that consuming too much acetaminophen can harm your liver. Adults should consume no more than 4,000 milligrams (mg) per day.

The difference between a safe amount of acetaminophen and one that may impair the liver, on the other hand, is quite little. The manufacturer of Tylenol, McNeil Consumer Healthcare, has reduced the recommended maximum daily dose to 3,000 mg. This recommendation is supported by a large number of pharmacists and healthcare experts.

When taking acetaminophen, other factors increase the risk of liver damage. For example, if you already have liver problems, drink three or more alcoholic beverages each day, or take warfarin, your risk of liver damage increases.

Stomach ache, changes in the color of feces, itching, and paleness of body parts are all symptoms of a pharmaceutical overdose. In certain extreme circumstances, skin responses may be observed. As a result, the doctor should be consulted as soon as symptoms occur.

The doctor should carefully check the patient’s health before administering drugs. This would assist him in prescribing the optimal dosage to the patient, lowering the chance of negative effects caused by excessive pharmaceutical ingestion.

Such drugs should be avoided by anyone who has any type of liver or kidney illness. Individuals who often consume alcoholic beverages should also visit a doctor before taking the medication.


Several people have inquired as to whether these drugs can be taken together. Both of these drugs have very distinct chemical compositions. Ibuprofen can reduce inflammation. However, Nyquil lacks these qualities.

However, keeping the recommended time gap of 3 hours is preferable. This would lower the likelihood of drug interactions and, as a result, the likelihood of side effects. Both of these medications, however, should be taken after eating to avoid the possibility of further stomach problems.


Editorial Staff

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