How Long After ZYRTEC Can I Drink Alcohol?

logo by Editorial Staff | Updated on August 2nd, 2022

Mixing alcohol and Zyrtec might have negative effects on your health. Combining these two has negative consequences on the brain. This can have serious consequences for the neurological system and the liver.

When using cetirizine, alcohol might produce dizziness, tiredness, and difficulties concentrating. Some folks may also have poor reasoning and judgment. You should avoid or restrict your alcohol consumption while using cetirizine.


If you’ve been taking allergy medication, wait until it’s out of your system before drinking. Diphenhydramine, loratadine, and cetirizine are most likely eliminated by the liver 2 to 3 days after administration.

What is Zyrtec?

Zyrtec is an antihistamine used to treat allergy symptoms such as runny nose, itching, sneezing, hives, and watery eyes. Cetirizine is the generic name for this medication. The medicine “Zyrtec-D” is not the same as Zyrtec. Cetirizine and pseudoephedrine are ingredients in Zyrtec-D. Pseudoephedrine is a decongestant that reduces sinus and pulmonary stiffness and pressure.

Zyrtec is often a safe and effective medicine when used properly and with particular precautions when taking any drug. Excessive usage of any medicine can have long-term consequences. Thus it is critical to take adequate amounts to minimize adverse effects. Extra Zyrtec dosages can cause major adverse effects such as dangerous drowsiness, xerostomia, hazy vision, and sweating. Zyrtec may also have the following side effects:

  • stomach ache
  • Diarrhea
  • Vomiting

The recommended daily dose for people under 65 and children above six is ten milligrams (mg). Doctors strongly urge that no more than 10mg be taken in 24 hours. Zyrtec syrup is indicated for children aged 2 to 6 years.

Antihistamine side effects

Check the package insert for a complete list of potential side effects and information on when to seek medical attention.

Antihistamines have the following side effects:

  • sleepiness 
  • reduced coordination
  • reaction speed and judgment 
  • dry mouth
  • blurred vision
  • difficulty peeing
  • headache
  • dry mouth
  • feeling sick

Are there any major dangers or adverse effects?

When using antihistamines alone, most people do not encounter major side effects or hazards. 

These drugs have been used by the general population for decades and are available without a prescription.

However, using diphenhydramine with alcohol might exacerbate some significant medical issues. Glaucoma, chronic obstructive pulmonary disease (COPD), and an enlarged prostate are a few examples.

Antihistamine Action

Antihistamines work by blocking the effects of histamine in your body.

When your body recognizes anything hazardous, such as an illness, it releases histamine. Histamine causes blood vessels to dilate and the skin to enlarge, which aids in the body’s defense.

If you have allergies, your body may perceive an innocuous substance as a threat and create histamine.

Histamine allergy symptoms include itchy, watery eyes, a runny or plugged nose, sneezing, and rashes.

Antihistamines can help prevent this from occurring if taken before coming into touch with the allergen. Alternatively, if taken later, they might lessen the intensity of symptoms.

Combining antihistamines with other medications

If you are already taking other medications, consult your pharmacist or doctor before using antihistamines. There is a possibility that the medications will interact with one another or enhance the risk of negative effects.

Examples of medications that may interact with antihistamines include:

  • Antidepressants
  • stomach ulcers or indigestion medications
  • cough and cold treatments with an antihistamine

Can You Drink Alcohol While Taking Allergy Medicine?

Combining oral loratadine (Claritin), oral fexofenadine (Allegra), or oral cetirizine (Zyrtec) with alcohol is usually seen to be safer. The effects of some drugs, such as sleepiness, are not exacerbated by drinking alcohol.

What Happens When You Combine Alcohol and Antihistamines?

Avoid drinking alcohol while taking an antihistamine, especially if it’s a tired variety since it might increase your chances of being tired. Most antihistamines are unaffected by food or drink but read the label instructions carefully.

What medication should never be combined with alcohol?

Dangerous Drugs When Mixed With Alcohol

Type of MedicationCommon Example(s)
AntibioticsAzithromycin (Zithromax), Doxycycline (Vibramycin), Erythromycin Metronidazole (Flagyl)
Blood pressure drugsCaptopril (Capoten) Felodipine (Plendil) Nifedipine Diuretics, such as hydrochlorothiazide
Blood thinnersWarfarin (Coumadin)

Is It Safe to Drink Alcohol If You Have Allergies?

Almost every allergy symptom, including sneezing, coughing, and itchy eyes, is exacerbated by alcohol. Consuming alcoholic drinks has been connected to allergy reactions. Alcohol decreases the quantity of allergen necessary to trigger an allergic response.


It is best to avoid combining alcohol and Zyrtec. When the hazards are combined, they might cause significant sleepiness and sedation. If blended, the individual may become inebriated more rapidly than usual, which can be dangerous owing to a lack of judgment or coordination.

If you have any more questions regarding combining alcohol with an antihistamine or general inquiries concerning the potential adverse effects and interactions of Zyrtec, visit a prescribed medical specialist.


Editorial Staff

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