How Long Can You Take Benadryl After Tylenol? Understanding the Safest Way to Combine These Medications

logo by Editorial Staff | Updated on September 30th, 2023

If you’ve ever experienced pain and allergies at the same time, you may have wondered how you could safely use over-the-counter medications like Tylenol (acetaminophen) and Benadryl (diphenhydramine) together. To put your mind at ease and provide you with accurate, trustworthy information, we’ve compiled the latest guidelines for combining these two popular medications.

A Closer Look at Tylenol (Acetaminophen)

Tylenol is an over-the-counter medication containing acetaminophen, primarily used for managing pain and reducing fever. Common conditions treated by Tylenol include headaches, backaches, toothaches, and even arthritis. This versatile medicine is also an active ingredient in many over-the-counter drugs designed to treat cold, cough, and migraine symptoms.

Benadryl After Tylenol

Understanding Benadryl (Diphenhydramine)

Benadryl is a well-known brand under which diphenhydramine is sold. It is an antihistamine designed to treat symptoms related to allergies, such as itching, hives, and sneezing. Besides allergies, Benadryl also offers relief from common cold symptoms like cough and runny nose. The medication typically reaches its peak effectiveness in two hours and can last up to seven hours.

General Guidelines for Combining Medications

While taking multiple over-the-counter medications, it’s crucial to read the labels carefully. The objective is to ensure that you’re not combining drugs with similar or identical active ingredients, which could lead to adverse effects or overdose. For example, it’s generally fine to take a decongestant, an expectorant, and a pain reliever simultaneously because they serve different purposes. But taking two decongestants is a no-go.

How Long After Taking Tylenol Can You Take Benadryl?

Age GroupTylenol Maximum DoseBenadryl Maximum Dose
Adults (weight ≥50kg)Less than 4000mgUp to 300mg
Children (age <12 years)Less than 3250mgUp to 150mg

Dosage Recommendations

When it comes to combining Tylenol and Benadryl, the good news is that these medications don’t have known interactions. However, always consult a healthcare professional for tailored advice. Adult dosages for Tylenol should not exceed 1000mg per intake and 4000mg within 24 hours. For children under 12 years, the recommendation is less than five doses in 24 hours, not exceeding 3250mg.

For Benadryl, adults shouldn’t consume more than 300mg per day, and children are advised not to go over 150mg. Note that these are general guidelines; your doctor might adjust them based on your specific condition, age, or concurrent medications.

Risks and Precautions

While Tylenol and Benadryl are generally considered safe, they are not without risks. Excessive use of Tylenol can lead to acute liver failure. Similarly, Benadryl can cause a range of side effects like high blood pressure, irregular heartbeat, mood changes, and dizziness.


It is possible to combine Tylenol and Benadryl safely, but the key is to follow proper guidelines and consult healthcare professionals for personalized advice. Traditional remedies like ginger, honey, and tulsi are effective for treating mild symptoms, but for persistent or severe conditions, medical intervention is crucial.

With medications, it’s better to be safe than sorry. Adhere to dosing guidelines and always seek professional advice for the safest and most effective treatment.


Editorial Staff

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