How Long Can I Take Benadryl After Tylenol?

logo by Editorial Staff | Updated on August 4th, 2022

Exact Answer: Benadryl (diphenhydramine) may be used safely alongside Tylenol (acetaminophen).

Tylenol PM is a combination of these two medications! Tylenol PM includes 1000 mg of acetaminophen and 50 mg of diphenhydramine in one dosage (two caplets). It is used to reduce discomfort while also assisting in falling asleep faster.

Benadryl After Tylenol

Concerning Tylenol

Tylenol (acetaminophen) is a nonprescription analgesic used to relieve fever and pain caused by headaches, backaches, toothaches, wounds, or arthritis.

Much over-the-counter pain, migraine, and cold/cough drugs include Tylenol.

Concerning Benadryl

Diphenhydramine is sold under the brand name Benadryl. It is a kind of antihistamine that is mostly used to treat allergies. This medicine can also treat typical cold, cough, and nausea symptoms. Benadryl has a maximum impact of roughly two hours and can last up to seven hours.

Diphenhydramine, the generic name for Benadryl, is an antihistamine used to treat dizziness, nausea, vomiting, runny nose, and sneezing. It has the same adverse effects as Tylenol, such as constipation, dry mouth/throat/nose, exhaustion, sleepiness, insomnia, drowsiness, and so forth.

General Guidelines

Most multi-symptom cold and cough drugs should not be taken at the same time. If you must take more than one prescription at the same time, carefully check the labels to ensure that you are not taking several drugs with the same or similar active components.

If you are taking meds for a specific ailment, it is generally OK to take multiple medications as long as they do various things. For example, taking a decongestant, expectorant, and pain reliever are OK, but taking two decongestants is not.

To make things a little easier, here is a list of some of the most common over-the-counter cold and flu drugs available in the United States.

Examine which ones may be securely mixed and which ones should not be. If you don’t find the drugs you wish to take on the list, go to your doctor or pharmacist to be sure they’re safe to take together.

How Long Can I Give Benadryl After Tylenol?

Age groupTylenol Doses
Adults (weight 50kg)less than 4000mg
Children (age 12 years)Less than 3250mg

Dosage recommendation

Tylenol and Benadryl have no known interactions. Thus they can be used together or separately as advised by a doctor or pharmacist. Tylenol can be taken as advice on the label or by a doctor. Tylenol should not be used with acetaminophen-containing medications. It has the potential to result in a lethal overdose.

Tylenol dosages vary depending on age group. People weighing at least 50kg should not take more than 1000mg at a time. It is not recommended to take 4000mg in 24 hours. Children under 12 must not take more than 5 doses of the medicine mentioned above in 24 hours.

Benadryl should be taken exactly as directed on the label or as directed by a doctor. Adults should not take more than 300mg of Benadryl per day.

It is recommended that children use no more than 150 mg per day. Benadryl spray should not be used more than 5 times per day. Both adults and children are affected by this illness.

Benadryl doses are determined by several factors, including your medical condition, age, and the type of drug you are taking. The body’s reaction to Benadryl may diminish with time.


It is possible to infer that drugs have several adverse effects and should only be taken when recommended by a specialist.

Tylenol includes acetaminophen, which is used to treat mild to moderate fever and discomfort; nevertheless, in addition to its effectiveness and popularity, it is also the leading cause of abrupt liver failure.

Benadryl contains Diphenhydramine, which inhibits the effect of histamine on capillaries, so lowering allergic symptoms. Aside from these effects, it also causes a rise in blood pressure, irregular heartbeats, mood changes, dizziness, and other symptoms.

Every coin has two sides, and drugs must be used cautiously to achieve the optimum outcomes. To treat common colds, nausea, and other symptoms, ancient Indian remedies such as ginger, honey, and tulsi should be used. If it is not treated, just one person should seek medical attention.


Editorial Staff

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