How Long Does Monistat-1 Stay Inside You?

logo by Editorial Staff | Updated on September 24th, 2023

If you’re one of the nearly one million women in the United States who experience vaginal yeast infections annually, you’re not alone. Among the many treatments available, Monistat-1 emerges as a convenient single-dose solution. So, how long does Monistat-1 stay inside you, and how should you use it effectively? This editorial aims to provide a comprehensive guide to using Monistat-1, answering all your questions and setting you on a path toward relief.

What is Monistat-1?

Monistat-1 is a combination pack specifically designed to treat vaginal yeast infections. This pack consists of a high-strength ovule insert for the vagina and an external itch cream for immediate relief. Candida yeast, naturally occurring in the body, can sometimes grow out of control and lead to infections. Symptoms often include a burning sensation, itching, redness, and a white vaginal discharge.


How Long Does Monistat-1 Stay Inside You?

Monistat-1 is crafted to provide ongoing relief for up to seven days, with no need for daily reapplication. However, during this period, it’s common to experience some medication discharge or leakage. To minimize this, it is advisable to apply Monistat-1 before going to bed.

Proper Use of Monistat-1: The Basics

Before you decide to self-treat using Monistat-1, it’s crucial to read all the accompanying product instructions. If any questions arise, don’t hesitate to consult your pharmacist. If a doctor has prescribed this medication for you, follow the specific guidelines provided.

Inserting the Ovule: A Step-By-Step Guide

The Monistat-1 pack comes with a single ovule insert that goes directly into the vagina. To use it, first open the pouch and insert the ovule into the wider end of the applicator. Once securely in place, position the applicator as far into your vagina as is comfortable, similar to inserting a tampon. Use your finger to push the plunger, releasing the ovule into your vagina. The ovule will gradually dissolve, releasing medication to treat the infection.

Application of the External Itch Cream

Alongside the ovule, the pack contains itch-relief cream for external application. You can apply this cream on the skin around your vagina for up to seven days, ideally twice a day—once in the morning and again before bed.

Over-the-counter (OTC) Treatment Options

If you experience occasional, mild to moderate yeast infections, OTC treatments besides Monistat-1 are also available. However, if infections are frequent, consult your doctor for stronger treatment options.

Short-Course Vaginal Therapy

Azoles, a class of antifungal medication, are the primary choice for treating yeast infections. They are available in varying dosages and forms like creams, tablets, ointments, and suppositories. Popular OTC options include tioconazole (Vagistat), miconazole (Monistat), and clotrimazole (Gyne-Lotrimin). These may cause minor discomfort or stinging upon application.

Single- or Multi-dose Oral Medication

In cases requiring long-term treatment, fluconazole (Diflucan) is often prescribed. Although generally safe, a strong single dose could lead to side effects such as nausea, flu-like symptoms, or a rash.

Long-Course Vaginal Therapy

For persistent infections, a 7- or 14-day pharmaceutical regimen might be recommended. Prescription-strength azoles like butoconazole (Gynazole), terconazole (Terazol), and fluconazole (Diflucan) are available in various forms.

Frequently Asked Questions

Can I use Monistat-1 during my period? 

Yes, Monistat-1 remains effective even when you’re menstruating. Just avoid tampons, which can absorb some medication.

How long does the ovule take to dissolve? 

The ovule generally dissolves within about 40 minutes, forming a coating on the vaginal wall to prevent leakage.

What to avoid when using Monistat-1? 

Opt for loose-fitting, natural fiber clothing and avoid tight, synthetic clothes that could exacerbate the infection. Also, Monistat-1 can weaken latex condoms or diaphragms, so consider alternative birth control methods during treatment.

Does Monistat-1 interact with any other medication? 

Yes, Monistat-1 can interact with Warfarin and may also increase the risk of yeast infections when used alongside antibiotics, corticosteroids, and immune system suppressants.


If your symptoms persist or recur within two months, it’s crucial to consult your doctor for a more potent treatment or to rule out any underlying health conditions. By being aware and informed, you’re already on your way to effectively managing and treating vaginal yeast infections.


Editorial Staff

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