When Can I Drink Alcohol After Taking Bactrim?

logo by Editorial Staff | Updated on August 2nd, 2022

Antibiotics have been shown to persist in the human body for a more extended period than other therapeutic medications. 

This indicates that this kind of drug is a little sluggish in efficacy. 


Because disulfiram responses to Bactrim and alcohol have been documented, it is advised to exercise caution and avoid the combination.

When Can I Drink Alcohol After Taking Bactrim?

Bactrim is readily absorbed when used orally, with peak concentrations occurring 1-4 hours after administration. As a result, drinking should be avoided for at least four hours after taking Bactrim. This may assist in avoiding any nausea or vomiting that may occur.

If a person takes Bactrim regularly, it is helpful to have detailed information on what to eat and what not to eat after taking the specified amount. 

Bactrim has a half-life of 8-12 hours (half-life refers to the time it takes your body to drop the concentration of the medication by 50%), which means it will take at least a few days for the whole medicine to be digested and eliminated from your system.

It is well acknowledged that alcoholic beverages slow down the body’s inherent metabolism. This indicates that the antibiotic will quickly lose its effectiveness if significant amounts of booze are drunk. 

Dullness may be elevated significantly in unwell patients, interfering with everyday living tasks.

However, a four-hour restriction is sufficient if the individual is physically fit. People suffering from various conditions, such as liver difficulties, must wait at least twenty-four hours after taking Bactrim orally.

The Dangers of Mixing Alcohol and Bactrim

To break down alcohol into something that can be readily removed, your body relies on particular enzymes. 

Several byproducts are produced as a result of this procedure. Acetaldehyde, a poisonous chemical, is one of the byproducts.

Bactrim may inhibit the enzyme responsible for the breakdown of acetaldehyde, resulting in a buildup of the poisonous chemical.

This interaction has the potential to have a wide range of adverse effects. Consider the following:

  • Flushing
  • Headaches
  • Vomiting and nausea
  • Breathing difficulties
  • Headache
  • Rapid heartbeat

These effects may appear five to fifteen minutes after consuming alcohol.

Extremely high blood pressure

When used with alcohol, a family of medicines known as monoamine oxidase inhibitors can cause dangerously high blood pressure, potentially leading to life-threatening events such as heart attacks. This class contains a few antidepressants, as well as the antibiotic linezolid.

MAOIs inhibit the breakdown of tyramine, a chemical in red wine, sherry, breweries, and fermented foods. As a result, tyramine can be found in alcohol-free and low-alcohol beers.

As a result, tyramine accumulates in your body. When there is an excess of tyramine, hormones such as adrenaline (epinephrine) and norepinephrine rise; these hormones cause your heart rate to increase in stressful or exciting situations. In addition, it can induce dangerously high blood pressure when consumed in excessive quantities.

To avoid this response, refrain from drinking alcoholic drinks for at least two weeks after discontinuing linezolid.

Serious liver injury

When combined with alcohol, isoniazid and ketoconazole may elicit symptoms of a disulfiram-like response.

These two medicines can induce liver damage and even liver failure, and combining them with alcohol enhances the risk of severe liver damage even more. 

Symptoms of a damaged liver may include:

  • Vomiting and nausea
  • Dark urine and feces
  • Pain in the abdomen
  • Yellow tinge in the eyes or on the skin
  • Chronic exhaustion

What Exactly Are Antibiotics?

Antibiotics, often known as antibacterial agents, are potent drugs that kill or inhibit bacteria development. Antibiotics do not treat viral illnesses like colds or the flu but rather bacterial disorders. Antibiotics either kill invading microorganisms or prevent antibodies from multiplying. While white blood cells in the body usually attack dangerous bacteria and heal the infection on their own, there are occasions when the amount of foreign germs is too high, necessitating the use of antibiotics to aid in the process.

Antibiotics are available in a variety of forms to treat a wide range of illnesses, including:

  • Throat infection
  • Bacteria cause pneumonia
  • Infections of the urinary tract
  • Diseases spread through sexual contact
  • Infections of the ears
  • Acne is one example of a skin infection.
  • Sepsis

When taken as indicated, most antibiotics are safe; nevertheless, many antibiotics include the potential for side effects such as upset stomach, nausea, and diarrhea.

When taking antibiotics, stay away from alcohol.

Drinking alcohol while on antibiotics can be dangerous. Alcohol not only has a negative interaction with some drugs and can produce severe adverse effects but also disrupt the natural healing process. Alcohol should be avoided until your antibiotic prescription has been completed and your body has had appropriate rest and nutrients.


Each person’s body reacts differently to different drugs, and the side effects vary greatly. Bactrim is a straightforward antibiotic that is widely used. However, some antibiotics are affected by alcohol in a variety of ways. The effectiveness or adverse effects may be affected when people drink while taking antibiotics.

People should be aware that any antibiotic’s stomach and digestion-related adverse effects may be exacerbated when used with alcohol.


Editorial Staff

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